Would rather lie in the north of Guangnan county the clinic of kind-heartedness hospital on the way has already stopped doing business now.

Would rather lie in the north of Guangnan county the clinic of kind-heartedness hospital on the way has already stopped doing business now.
Special one kind " The pig " Go abroad, come Nanjing already the beginning of the year, perhaps in the near future, doctor can transplant the organ of pig into human body, agony used for saving the patient's life, relieving disease. Nanjing expert of medical university announce recently, they clone one " whether gene knock at and get rid of the transgenic pig " ,The first batch of pig's babies would be born in early summer of this year. This kind of pig will cause the gene of human body's ultra acute immune rejection to be struck in the body and remove, from theory, it will not initiate the main rejection either that his various organs transplant to people. Hi-Tech " Strike and eliminate " Repel the gene and introduce this kind of pig the domestic one, " returning in the sea " Zhao Zi builds, wears the group of experts of 6 people that all professors headed the list of signers. Research that they are engaged in molecular genetics in the medical college of University of Pittsburgh before this, it is being international top that bringing at the end of last year " The gene is struck except that the pig " Technology gets back to at home, settle in the supersession disease research center of medical university of Nanjing. Zhao Zi builds a professor to introduce, launches the important route that different kind of organ transplant is a universally acknowledged settlement organ in short, because pig the intersection of organ and size and function compare with human organ identical reproduction easy, regard pig as the first-selected animal of different kind of organ transplant sources of the human body in the world. And replace the human body with pig's organ " The scrap organ " ,The more important thing is to solve the rejection. "What is called transgenic pig, just uses modern genetic engineering, makes the pig apt to cause the gene of the main immune rejection to remove on one's body, make the pig organ transplanted survive with the human body inclusively and for a long time. " Wear to all professors and introduce, the candy molecule not containing a kind of mankind on pig's endothelial cells of blood vessel, plant as the intersection of pig and organ into behind the human body, immune system of human body will take exotic as and initiate attack the the intersection of candy and member, can destroy transplanting the organ in several minutes. So, to solve this problem, one should " strike " Produce the gene of this kind of candy molecule in pig's cells. As far back as 2002, wear first all seminar cultivate in U.S.A. right away " the single gene is struck except that pig " ,Cultivated again later " One pair of genes is struck except that the pig " ,Have solved " The extremely acute immune rejection " ; On this basis, they still give pigs cells to change over to some people's gene, carry on " sources of people " to it Decorate and transform, cultivate and does not basically include " repel the gene " " last transgenosis pig gene " . Wear allly and say, they transplanted the cornea of the transgenic pig, Langerhans' islits to the big animal before this, the rejection has not taken place. " two generations of pig " Could be used for transplanting Clone out in the first batch " A generation of pig " Can't be used in clinical trial directly yet, must breed one more generation, become " two generations of pig " Will be used in the experiment. Want, transplant people to because of organ of pig these, must prevent pig from in the body getting endogenous virus travels in the human body. Wear allly and say, if All goes weight, it is estimated the eyes cornea, skin of the pig are transplanted and can be used in the clinical trial fast, can realize within about 1 year; Langerhans' islits, transition liver take about 2 years; Permanent heart, kidney, liver need fixing again according to the progress that the gene transforms, estimate that can realize the goal in about 5. " But Zhao Zi builds adding, it is not actually what the scientist can decide whether could really have clinically, this also needs relevant government department to sanction. "Our pig should be like software constantly ' upgrade '. " Zhao Zi builds and says humorously, " these pigs are transformed by deeper ' sources of people ' gene in the future, hope that be able to not almost there is not rejection. Perhaps people can even customize one's own organ on pig in the future. " Treating the transgenic pig and moving towards the clinical transgenic pig's subject of this front in discretion attracts numerous experts in our country to pay close attention to, but a lot of when to different kinds of transplantation expert can move towards maintaining a very scrupulous attitude clinically still. "This is a very promising scientific research project. " Burn clinical expert that treats and cures, Shanghai Rui Jin hospital and would rather teach and say to burn Huan Beijing of the head of the department for a long time, "in clinical at present the large area burn patient often employs the pigskin, but the reason repelled because of the immunity, the fresh pigskin is repelled after transplanting wound surface for 7- 10 days. So, research and develop the gene and transform the pigskin, it is expected to lengthen the time that the immunity repels to a certain extent, reach the comparatively ideal result. " But he say, want, serve as clinical biomaterial the transgenic pigskin at the same time, must go through primate testing, agreeing, medicine supervising the department and sanctioning and such numerous linkses as clinical trial, expert confirm of ethics committee, the procedure needing going is very long and very strict too. The biochemical cell researcher of research institute Xiao Lei in Shanghai of Chinese Academy of Scienceses have led the group to cultivate the multi-functional stem cell with the body cells of the pig for the first time in the world. He reveals while giving an interview, the country has already started a great direction project at the end of last year, he and it wears all to be seminar members. Xiao Lei says, such multi-functional stem cell which they fostered is like embryo's stem cell, can develop into any type of cells in the body. This achievement, in order to decorate and produce pig, cultivation which tolerates diseases such as pig's influenza,etc. for the transgenic animal of human organ transplant to open up the new road through the gene. He thinks, " different kind of transplantation of large-scale organ such as the kidney of the pig still face a lot of technological problems, but it can be in order to solve to believe step by step with the development of technology. " The researcher thinks presenting the situation that it is expected to relieve support the body to be nervous of the transgenic pig. "This pair of patients who waits for organ transplant are undoubtedly a good news. " China medical ethics learns the president, Sun MuYi of professor of Southeast China University how to give affirmation to this, but he points out again, " we should still investigate the level of their research and feasibility calmly, strictly, scrupulously at the same time. Development of life sciences belong to person who surmount often now, this need the intersection of government and related departments keep up with in time, make relevant the intersection of entry and rule, appraise system,etc., bring into schedule. " (Lee garden)

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