Battle of supersession syndrome

Battle of supersession syndrome
From naming, making a reservation to treat, the dispute of supersession syndrome has been never disconnected. It is the problem that a clinician needs to think deeply how reason is thought about this one and disputed. This edition invites the authoritative expert paying close attention to this problem to discuss one's own view. Chinese-Japan Friendship Hospital the intersection of endocrine and the intersection of metabolic disease and Li, Professor of centre, big 1988 such as background Reaven proposed X syndrome only, original intention is to help to be diagnosed in early days. From then on, people were growing on and on to the interest of this syndrome closely related to cardiovascular critically ill dangerous factor. Continue WHO in 1998 and propose supersession syndrome (MS) After the work was defined, European insulin resisted the seminar, plans for education of national cholesterol in U.S.A. put forward one's own definition in succession in 2001 in 1999, international diabetic alliance (IDF) in 2005 Have proposed the new definition of supersession syndrome. However, because of the joint statement of ADA/EASD, make it fall into swirl of disputing in recent years. The joint statement thinks, supersession syndrome defines it is not accurate enough, has not put forward the precise cause of disease, whether it has a common pathologic course of foundation that unidentified; The whole MS might not be superior to the danger that the single component express to the value predicting CVD is dangerous; MS does not have particular treatment,etc.. Even someone criticizes this syndrome and was invented by some pharmaceutical factories. The proposition of battle supersession syndrome named, actually on the basis of some extremely familiar clinical phenomena of everybody, namely in the crowd resisting in insulin, though compensating high insulinogenic blood disease keeps the sugar tolerance normal or is close normally, have prevented the occurrence of diabetes, but insulin is resisted / the dangers of unusual, fat supersession disorder and essential hypertension the sugar tolerance takes place and increase greatly to the high insulinogenic blood disease patient, the danger of the cardiovascular disease take place and obviously increase too to them. Proposed X syndrome, because can not understand insulin resisting and meaning yet at that time. And consequence have understand in depth a lot of the intersection of endocrine and expert think, call insulin as, resist syndrome it with resist to insulin. WHO puts forward the work of supersession syndrome and defines the key function that has emphasized too insulin resists. In the view of many experts, call supersession syndrome, have a can with simple and convenient to measure index and method that insulin resists while being practical, standardization is very difficult too that insulin is determined. Accord with supersession syndrome and diagnose whether the person of the condition has insulin to resist? This is really a practical problem. It is not but a kind of disease but a kind of physiological state that insulin is resisted, it brings about the danger of metabolic disorder in close relation with cardiovascular vessel disease in people to greatly increase. The purpose to put forward insulin and resist the concept is not in order to be diagnosed, but in order to further find out about the pathologic physiology of disease. Propose supersession syndrome is different, its purpose is to make clear diagnosis, and advise patients to change the life style in view of the above and reduce the energies and is in charge of the danger. So by the look of angle diagnosed, people are more willing to call that supersession syndrome. Battle making a reservation " the pathogenic ability of supersession syndrome is not stronger than the total of its every component " Query one of the important contents that syndrome is valuable in ADA/EASD declares. Is this a fatal weakness of syndrome? It is certainly very good that the pathogenic ability of syndrome is stronger than the total of its every component, prove that has cooperative effect in the pathogenic respect between every component; But the total that the pathogenic ability of syndrome is not stronger than its every component gives no cause for much criticism, because propose another important function of syndrome is " The falling of one leaf heralds the autumn " ,Namely it is multifactor to find in early days and assemble in one suit, it is much better than to only find the single dangerous factor. It is that another one is censured that the pathogenic ability of syndrome is not independent of its every component. This kind is censured and come from statistical analysis not appropriate more and made the explanation not appropriate to the result of statistical analysis. For instance, after some people adjust the influence of blood glucose or blood pressure, see the pathogenic ability of syndrome. This has made the fatal mistake in fact: Adjust one whole some part ' It is an extremely important part of it sometimes) Influence,then not come assess on this piece whole function,unreasonable just like assessing by ability to work of him arm cut down by one later. Another question that everybody pays close attention to is: Supersession syndrome has two kinds of prediction functions, first, predict diabetes, second, predict CVD is dangerous. The concept here is really a little confused, because the present supersession syndrome crowd has already included diabetes inclusive, predict diabetic oneself is obstructed to the reason with diabetes. There is a kind of inclination in the research of syndrome to metabolize at present, put a lot of diseases with already very clear cause of disease under the category of supersession syndrome again, this will cause the confusion on the concept, there is not any benefit to the clinical treatment. Some diseases are just called syndrome to their causes of disease when not knowing clearly because of people, if the cause of disease has been already clear, it is unnecessary to put under syndrome with unidentified cause of disease again. The battle treating, to the intervention in early days on physiological foundation of common pathology of supersession syndrome, can contain or reduce the forming of the critically ill dangerous factor of blood vessel of many center, is up to the prevention results of a stone and more than birds, this concept that is supersession syndrome prevents and cures the important reason why the field is accepted at cardiovascular disease extensively. But remain in the present medical practice " A stone " It is difficult to seek - -It makes syndrome disintegrate overallly not to find the particular medicine. Someone thinks since not in treating Yes " Shut " ,Still differentiate treatment each component, propose this syndrome is a little uncalled-for. It is obvious at present in on the intersection of supersession and syndrome treat " Do nothing " ,Have really offered a chance to the person who denies supersession syndrome. Metabolize syndrome at present and treat to choose to put clinically in the intervention of the life style especially. Some medicines such as dose list ketone types and one pair of guanidine and resist diabetic medicine and angiotensin and change the function that enzyme inhibitor improves insulin and resists, but not been orientated as and has treated supersession syndrome yet. People are expecting in this respect the safe and effective weight-reducing medicine can play a beneficial role in the future supersession syndrome treatment. The theory meaning in which this concept puts forward lies in exactly in fact metabolizing syndrome, it will impel people to pay attention to noticing in society transition the unhealthy life style will cause energy to take in and exceed the energy consumption, it is disorderly and spreading out and falling ill to pay attention to the physiological change to produce a series of supersession. The idea of prevention and cure of disease should be set out wholly and looked for one's roots to trace to the source at this moment, recommend changing the bad life style in a more cost-effective manner, reduce the fat, by preventing the development of this direction.

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