Imitate frog's inductor and is developed successfully It is expected to replace endotoxin to measure reagent

Imitate frog's inductor and is developed successfully It is expected to replace endotoxin to measure reagent
Organizing the recent report of network according to the American physicist, the researchers of Princeton University pass the antibacterial principle of studying African claw frog, developing one can be used for finding whether medicines and medical apparatus are the inductor which the bacterium pollutes. The new inductor not merely can replace present common endotoxin and measure reagent (LAL) ,It is expected to make the quantity of two kinds of endangered species no longer drop. Will produce peptide (two pieces or more amino acids dehydrate and condense and form several peptide keys on the skin of the African claw frog to make up a peptide) that can resist the bacterium ,Make it avoid infecting, people can formate out this kind of peptide in the laboratory now. The research group that space technology associate professor Michael and MacAlpin of machinery of Princeton University and aviation led has found a new method, can plant this peptide " Stick to " On the small electronic chip, when such electronic chip touches harmful bacteria such as Escherichia coli and salmonella,etc., the electronic chip will send out the electronic signal. MacAlpin expresses on " institute's publication of American national academy of sciences " published on October 18, this is a simple and powerful platform. Such electronic chip can be replaced and used for testing the endotoxin whether medical apparatus and medicines are infected measures reagent at present. The present common endotoxin measures the defect of reagent to lie in: It needs Hou (horse's hoof crab) Blood. This leads to the fact the quantity of Hou is reduced greatly in recent years, therefore cause the quantity of birds taking Hou as food to drop constantly too. Hou is a kind of old living beings with a history of 450 million years, there are " living fossils " It claims. Because its immune system has already evolved very well, contains the cells that can resist the bacterium in its blood - -Out of shape cell, make it avoid attack of bacterium, protect skin of the African claw frog from bacterium's attacking like peptide, so, it is very suitable for use in testing the bacterial infection. In 1965, scientists used and made LAL from the material that is drawn out in the blood of Hou, used for testing whether medicines and medical apparatus are polluted. In order to produce LAL, people catch Hou without restraint, before putting back it the ocean, people will collect their 30% of the blood. The report of the geological investigation bureau of U.S.A. reveals, the fatality rates of this method may be up to about 30%. Ecological research and an investigation of guarding of development institution reveal, Hou and relying on the quantity of its red belly bank snipe that made a living to reduce. MacAlpin group hopes this kind of technology based on electronic chip can replace LAL finally, the pollution as a kind of standard tests the means, let people " say good-bye to " from now on Hou's blood, let the quantity of the red belly bank snipe rebound too. Meanwhile, making such new inductor will not bring the pressure to African claw frog either. MacAlpin says, while making this kind of inductor, the claw frog will not be injured. This research has got the American asthma foundation and subsidy of the scientific research bureau of air force. (Liu Xia)

|