Show the meticulous hereditary atlas of sub area to draw outside the mankind

Show the meticulous hereditary atlas of sub area to draw outside the mankind
It is reported ' Reporter Li TianShu) On October 4, the big genetic research institute of China of Shenzhen announces, units such as this institutes and University of California Berkeley branch schools, Denmark Copenhagen university,etc. cooperate, showing the sub area outside and paying and checking order deeply of the gene through encoding 200 people's protein, have found a large amount of was clicked in the unknown many attitude location of single nucleotide in the past, among them the majority appeared in the crowd for lower frequency. Research this finish, show sub the intersection of area and of the largest scale, the intersection of resolution ratio and most meticulous hereditary atlas outside mankind at present not merely, indicate the hereditary variation may cause the production of the complicated disease at the same time. This research is issued in " natural science of heredity ". Complicated disease happens under multifactor common function, such as a plurality of mutation of a plurality of genes, a gene, environmental function and unknown random factor, the hereditary mode is more complicated. To complicated disease, each genetic influence is limited, non- enough to cause a disease alone. Complicated disease morbidity relatively high in ordinary crowd, such as schizophrenia, diabetes, cancer,etc.. Showing 18654 code genes of sub area to catch and check order outside to 200 Danes of this researcher, have found many attitude location of nucleotide of 121870 forms to click together. Researchers verify, influence the human health and many attitude location easy to be perceptual of disease to click and often present the frequency low, but the number clicked in relevant location is numerous. Past research location order go on, determine, appear low frequency to these attitude location order study enough much to common many attitude usually, thus miss a large number of disease related location to click, cause " the heredity degree is lacked " . The intersection of research and red cooperative the intersection of diabetes and related gene in being this and make a variation to study (LUCAMP) A part of the project. The research results contribute to constructing the mutant intact atlas of the human genome, and can also be used for explaining heredity drifting about, mutation, recombinating and choosing of the human genome,etc.. It is introduced, it is a part of the biological gene of real core to show the son outside, are also called and expressed arrays. Before this, Shenzhen the intersection of China and old genetic research institute adopt, show sub group check order technology show the son to carry on the research of checking order to 50 the intersection of Tibet and clansman outside outside, and find and hide the candidate gene that clansman's plateau adaptability is closely related with.

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