Who adjusts and controls people's embryo's early organ takes shape

Who adjusts and controls people's embryo's early organ takes shape
It is reported ' Reporter Hu DeRong) The scientist of our country makes the new development on human embryo's development. Relevant experts think, that these research is set up only people in the world, the organ forms a gene expression table type in early period, for explore human the intersection of development and early molecule adjust and control with the intersection of people and multi-functional the intersection of stem cell and external orientation inducing, splitting up, offering valuable messaging. Relevant research is by living beings money tip and Zhang Ji of key laboratory of research institute of Shanghai life of Chinese Academy of Sciences / healthy stem cell of scientific research institute of Shanghai Communications University medical college The seminar finishes, study the thesis and publish in the internationally famous academic publication " development cell " the magazine of July issue is had. It is introduced, burn the intersection of person and the intersection of embryo and development behind the bed contain the organ forms the most key period early period such as embryo, namely from embryo's development on the 20th day on the 32nd day to embryo's development. Change the angle to watch from the development shape, each organ has been gone through from having to some wonderful course; Evolve in the angle since development and watch, this wonderful course is highly guarded; From the viewpoint of latent energy of development, doing latent energy and differentiates the procedure harmony of set space-time of latent energy and changing. The molecule foundation of back of these changes is that the hereditary information express the accurate genetic interaction network that adjusted and controlled. Under study for action, are limit to the limiting of people's embryo's research sample and ethics, so the molecular mechanism about people's embryo's development is known little about. Researchers cooperate with the subsidiary gynaecology and obstetrics of Xinhua hospital of Shanghai Communications University medical college, use the genetic chip to carry on gene expression and change the table and study at 6 continuous stages at embryo's development of early organ, excavate and combine the function, duplicate adjusting and controlling, database with relevant phenotype and disease through the profound level of the data, the ones that find the whole embryo's shape change is changed by two groups of gene expression table influence: The gene reduce the variation tendency graduallying is responsible for the early organ initially, raise the gene changed and mainly participate in the original base of organ to take shape gradually. Scientific research personnel still find under study for action, the interaction network in people's embryo's early organ forming process, by two pieces of thinning module correlated to doing (hStemModule) With the module (hDiffModule) correlated with splitting up Composition. Collect analyzing to find richly through the little mouse phenotype, hStemModule may cause death with the embryo in early days and is correlated with, but hDiffModule may be correlated with causing death after being born in.

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