Urge the new inflammatory factor receptor of metastasis of cancer of mammary gland to be found

Urge the new inflammatory factor receptor of metastasis of cancer of mammary gland to be found
It is reported ' Reporter Wang Dan) A few days ago, Zhongshan University the intersection of ease and celestial being Sun commemorate the intersection of hospital and Song ErWei group and the intersection of China and scientific and technological the intersection of university student and the intersection of life and the intersection of academy of sciences and the intersection of snow and young tiger's group Yao that Professor head, separate and appraise the receptor of the inflammatory factor CCL18 which influence the metastasis of cancer of mammary gland for the first time in the world - -Membrane albumen PITPNM3, and find that can inhibit the shifting of breast cancer cells through inhibiting this receptor. This research results have already issued burning in world on April 12 on the medical periodical " cancer cell " of the name. Study and show previously, the reason why breast cancer cells are shifted, it is not that the inflammatory response of the controllability is in close relations instead of being around. Song ErWei group, through studying, has found a important one is not the inflammatory factor of the controllability in breast cancer is organized in recent years, namely the relevant macrophages of tumour can promote infiltration and transformation of breast cancer cells by secreting the inflammatory factor CCL18, the more this macrophage is, the greater probability the lymph node and what the organ is shifted takes place to the breast cancer patient, the worse the prognosis is. So, intervene the secretion of CCL18 of relevant macrophage of tumour, can inhibit the transformation of breast cancer cells obviously. And the corresponding receptor of CCL18 has never been found, has restrained the medical circle from directing against the treatment tactics of CCL18. It is reported, world burns famous scholar AlbertoMantovani professor and his review which the colleague publishes a concerted for the above-mentioned research thesis think, the discovery of the receptor membrane albumen PITPNM3 of CCL18, it is significant in the tumour prognosis is assessed. Research this open up one from the intersection of controllability and inflammation react, set about, inhibit the intersection of mammary gland and route of metastasis of cancer, have established the foundation for treatment antibody and small molecule compound which developed tumour.

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