Good-for-nothing 2HG carcinogenic mystery analyses and explains the human supersession

Good-for-nothing 2HG carcinogenic mystery analyses and explains the human supersession
It is reported ' Reporter Sun GuoGen) Glioma and leukemia are all human tumours with higher malignant intensity. The group of cell biology research office of biomedical molecule of research institute of Fudan University, through concentrating on studies, find one is " 2HG" Metabolite last function as leukemia machine-processed. This has been broken through already in issuing the internationally famous periodical " CancerCell " studied at tumour as the cover story on January 18 newly. Studies have suggested, enzyme different citric acid of supersession in the human body desaturase mutation and emergence, development of glioma have close relations, but the detailed mechanism of leading to the fact this tumour takes place and cancerates is not clear. Jump, in charge of good and the Zhao 's femaly and jointly tackle key problems with the bear of cell biology research office of biomedical molecule of research institute of Fudan University, verify different citric acid in the carcinogenic possible mechanism of mutation of desaturase at first, further propose because different citric acid desaturase influences the activity in human cells, and then carcinogenic new concept, and took the lead in reporting this research results on the international top publication " Science " in 2009. Hereafter, a research of the American scientist verified, after different citric acid desaturase mutation, will turn into and accumulate one in human cell " 2HG" Metabolite. Because 2HG accumulates in the cancer cell, it may be a carcinogenic " arch-criminal " . But 2HG carcinogenic the intersection of function and mechanism nobody knows. Yue, female good and Zhao Xiong the people lead the intersection of student and Wei and Yang Hui Xu,et al. of them generation, uniting the relevant scientific research personnel of Fudan University begins to be the new round of to tackle key problems hard. Their latest result of study proves, the supersession wastes that 2HG turned into and accumulated after desaturase mutation as different citric acid, usually the content is very low in human cells, but if 2HG accumulate in a large amount, will promote the transformation to the cancer cell of normal cell. 2HG accumulate can inhibit from, include histone go methyl enzyme and DNA go the intersection of methyl and a plurality of important pair of vigor with oxygen enzyme inside of enzyme in the human body directly while being too much, and pair adds oxygen enzyme can control biological enzyme of many kinds of cell functions in the human body, if their activity is reduced, may lead to the fact cancer takes place. That is to say, after a pair of vigor with oxygen enzyme is reduced, will change hyperplasia and growth way of cells, and then bring out tumour. People the intersection of histone and methyl in the cell horizontal level to go the intersection of methyl and vigor of enzyme control by histone, controlling well, people will not suffer from cancer; On the contrary, it is apt to suffer from cancer. " CancerCell " thinks in its draft of news briefing, the above-mentioned research results may play a positive role in looking for new glioma to treat the target and is clicked.

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