Body cells " Turn into the body " Induce the multi-functional stem cell's mechanism part to expound

Body cells " Turn into the body " Induce the multi-functional stem cell's mechanism part to expound
It is reported ' The easy reporter of reporter Lee's weather Zhu DanPing) Recently, the intersection of Chinese Academy of Sciences and the intersection of Guangzhou and biological the intersection of academy of sciences and scientific research group that Professor head the list of signers, minister of end, Pei, have expounded body cells partly " Turn into the body " In order to induce the molecular mechanism of the multi-functional stem cell - -Vitamin C and histone go methyl cooperative effect of enzyme, play an essential role in inducing the production of the multi-functional stem cell. This research results are issued on the academic periodical " cell stem cell " of international authority online, and is selected as the cover story. In 2006, Japanese scholar stretched and filled and became from the little mouse that obtained the multi-functional stem cell of induction whose function was similar to embryo's stem cell in body cells for the first time in the world in the mountain, namely iPS cells. Induce multi-functional stem cell to be application prospect extensive, it induce mechanism to be unidentified inducing the intersection of efficiency and issue such as being low perplex scientific circles for a long time. In 2009, researchers such as Pei DuanQing,etc. will find vitamin C can raise body cells to turn into the efficiency which induce the multi-functional stem cell greatly for the first time, but the reason is not clear. In order to explore the mechanism behind this phenomenon, in more than two years, Pei DuanQing studied the group to carry on a large amount of basic research, have found that restricts body cells " Turn into the body " Molecule obstacle,it is and in vitamin C want " cross over " enzymes special through one kind This kind of molecule obstacle thus improves body cells " Turn into the body " Efficiency. It is reported, researchers, through screening in a large amount, has found enzyme that can raise the heavy programming efficiency of cell notably - -Histone go methyl enzyme. Vitamin C and this kind of enzyme can facilitate body cells to grow with higher speed, have cooperative effect. The result of study reveals, any -treated body cells - -Can it becomes to be fibrous cell go down to posterity, get 6 generation wear out nearly outside body " Turn into the body " It is a multi-functional stem cell. Add vitamin C and histone, go methyl behind the enzyme, become fibrous cell go down to posterity get 12 generation outside body, have not demonstrated the old and feeble phenomenon yet, can keep " turn into the body " like original cell Latent energy, maintain heavy programming efficiency. Researchers point out, this discovery is expected to find a production to induce multi-functional stem cell's more simple and more convenient method, with big influence to fields such as stem-cell research and regenerated medical science,etc..

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